Profil de Cécile BEN
Email : benSPAMFILTER@ensat.fr
Téléphone / phone: +33 5 34 32 38 92
Bureau / office : n° 18
Institution : INPT
Statut / status: Enseignant chercheur
Assistant Professor in Plant Genetics & Functional Ecology
Engineer in Agronomy
|2008-Present||Assistant Professor, Laboratory ECOLAB (UMR5245 CNRS/INPT/UPS), INP-ENSAT, University of Toulouse, France|
|May. -Oct. 2014|| |
6-month Visiting Research Scholar, Sergey Nuzdhin’s Lab, Molecular and Computational Biology Program, College of Biological Sciences, University of Southern California, Los Angeles, USA
'Consulting for USAid Program ‘A reverse-introgression and community genomics strategy to enrich and characterize legume germplasm for climate-resilience’
|Oct. 2006 – Jan. 2008|| |
Postdoctoral Research Associate, Laboratory of Plant Symbiosis and Pathology, INP-ENSAT, University of Toulouse, France
'Positional cloning of a QTL of resistance to the root pathogenRalstonia solanacearum in Medicago truncatula'
|Oct. 2005 – Sept. 2006|| |
Postdoctoral Research Associate, Laboratory 'Development, Morphogenesis and Evolution' UMR 8080 CNRS/Paris XI University, Paris, France
'Study of the role for microRNAs during embryogenesis and metamorphosis in Xenopus tropicalis'
PhD. in Plant Genomics & Development, INP-ENSAT (National Polytechnic Institute-National Institute of Agronomy), University of Toulouse, France
'Transcriptome analysis of early embryogenesis in sunflower (Helianthus annuus)"
|2001||Master of Science in Plant AgroBioSciences, University of Toulouse, France|
|2001||Engineer in Agronomy, INP-ENSAT (National Polytechnic Institute-National Institute of Agronomy), University of Toulouse, France|
-‘Research and Ph.D Supervision’ (PEDR and PIR) since 2014 (national promotion)
- 'Léopold Escande' Award, from ‘National Polytechnic Institute of Toulouse (INP)’ awarding the 10% best PhD theses of the year
- 'Picot de Lapeyrouse' Award from the'Académie des Sciences de Toulouse' awarding each year one PhD thesis in biology
-Participation to the BLÅTAND Program 2015 (organized bythe French Embassy in Denmark)
Scientific trip to visit Danish research institutes to initiate collaborations.
-Participation to the EGIDE Zhang Heng Program 2011 on ‘Biodiversity & Sustainability’(co-organized by the French Embassy in China and the Chinese Academy of Sciences)
Scientific trip to visit CAS institutes to initiate collaborations. 7 young French researchers selected by French scientific experts and the French Embassy in China.
-CNRS Postdoctoral Fellowship (2005-2006)
-PhD Fellowship from the French Ministry of Higher Education and Research (2001-2005)
I am a plant geneticist from the University of Toulouse in France. With my colleagues in the ECOLAB laboratory, I am studying plant adaptation to environmental stresses (either biotic or abiotic) using the wild legume Medicago truncatula as a model.
By making use of the wide biodiversity existing within this plant species and based on whole genome re-sequencing data of natural accessions, we aim at identifying key genetic factors (genes and small non-coding RNAs) involved in adaptive process to changing environment.
By combining genetic and large-scale genomic approaches with population genomics, we intend to understand population structure and history as well as the contribution of micro-evolution in adaptation to environmental stresses.
Major Current Research Topics
'Genetic and molecular analyses of the natural biodiversity in legumes to identify adaptation mechanisms to environmental stresses'
- Biotic stresses: Root diseases caused by the soil-borne pathogens Ralstonia solanacearum & Verticillium sp.,
- Abiotic stresses: heavy metals (cadmium), salinity, drought
- Micro-evolution & Plasticity
‘Study of the adaptive contribution of small RNAs to legume root biotic interactions'
‘Biogeography analysis using patterns of genetic variation within modern plant accessions to reveal ancestral genome admixture and to infer population adaptation in the wild legume species Medicago truncatula'
PhD student co-supervision and training
|Oct. 2013-2016||Co-supervision of Mélanie Mazurier, PhD student at ECOLAB studying the ‘Biodiversity and adaptation of the tolerance to root pathogens in Medicago truncatula. Importance of the micro-evolution’|
|2010-2014||Co-supervision of Maoulida Toueni, PhD student at ECOLAB studying the 'Mechanisms involved in the interaction between Verticillium alfalfae and Medicago truncatula'.(Ben et al., 2013; Toueni et al., 2016)|
|Oct. 2013||Training of Saoussen Mahfoud, PhD student at the CBBC (Tunisia), in the frame of a PHC Utique international collaborative project, studying the ‘Genetic bases and physiological mechanisms of the interaction salinity/pathogens in Medicago truncatula’|
|Oct. 2013-2016||Involvement in the supervision of MS Yanis Amokrane & Adel Kadri, PhD students at the ENSA Alger (Algeria), in the frame of a PHC Tassili international collaborative project, studying the ‘Characterization of the genetic diversity among the Algerian collections of Medicago truncatula’ & ‘Identification of QTLs for resistance to drought in the model legume Medicago truncatula’ respectively. (Kadri et al., submitted; Amokrane et al., final preparation)|
|2010-2012||Training of Azam Negahi, PhD student at ECOLAB studying the 'Genetic basis of resistance to Verticillium wilt in Medicago truncatula' for genetic analyses aspects (use of molecular markers, genetic mapping, QTL detection).(Negahi et al., 2013; 2014; Ben et al., 2013)|
|2008-2011||Involvement in the supervision of Sondes Rahoui, a visiting PhD student from the Univ. of Bizerte (Tunisia) studying the 'tolerance to cadmium in Medicago truncatula'. Training on bioinformatics and molecular biology.(Rahoui et al., 2014; 2015; 2016)|
|Nov. 2012||Training of Maroua Gharbi & Nadia Zitouna, visiting PhD students from the Univ. of Tunis (Tunisia) studying the ‘Genetic biodiversity in Sulla plant species’ for genetic analyses (use of molecular markers, genetic mapping, QTL detection).|
- From Jan. 2016, Deputy Head of DYNABIO research team at ECOLAB laboratory.
- Elected member to the‘Conseil des Etudes et de la Vie Etudiante’ at the INP-ENSAT since 2014.
- Elected member to the Board for Recruitment of Assistant Professors at the INP-ENSAT since 2010.
Elected Secretary of the Board from Jan. 2015.
Member of a selection jury for the recruitment of an assistant professor at the INP-ENSAT in 2012.
- Member of the organization committee of the Mini-Symposium on ‘Medicago Genetics & Genomics’, Port-La-Nouvelle, France, 14th-16th Sept. 2015 (17 participants from 4 nationalities).
- Member of the organization committee of the International Model Legume Congress 2011, Sainte-Maxime, France, 15th-19th may 2011 (150 participants from 23 nationalities).
- Publication of a vulgarization article in the ‘Magazine du CNRS en Chine n°19 – Printemps/Eté 2015’. Ben C. ‘Adaptation des plantes aux stress environnementaux : le projet MeToliCa’, French and Chinese versions, http://www.cnrs.fr/derci/IMG/pdf/cnrsenchine_19_print-ete2015.pdf,19 :33-35.
- Member of PhD Thesis Scientific Advisory Boards
Liné Clarisse on the 'Influence of the physico-chemical characteristics of carbon nanotubes on their effects on plants', co-supervisors: C. Larue (EcoLab) & E. Flahaut (CIRIMAT), Toulouse, France (Jan. 2017).
Ghazanfar Abbas Khan on the ‘Study of the role of miR396 in the root meristem activity in the legume Medicago truncatula’, co-supervisors: C. Lelandais-Brière & Martin Crespi, ISV, Gif/Yvette, France (Feb. 2010).
- Supervision of high school students for the scientific challenge ‘Faites de la Science 2006’ for a project on ‘Universality of the genetic code’ (Univ. Paris Sud XI, Jan-May 2006). ‘Biotechnologies’ Prize.
INTERNATIONAL SCIENTIFIC CONFERENCES
Ben C, Mazurier M, Tatarinova T,Gentzbittel L.(Nov. 16 & 17, 2016)“Could an integrative approach merging whole-genome and bio-climatic data help in developing innovative biodiversity-based cropping systems to mitigate global climate change impacts?”, IVème Journées Scientifiques Internationales de l’INAT, Tunis, Tunisia.
Ben C, Toueni M, Mazurier M, Negahi A, Sbeiti A, Tatarinova T, Turner M, Shamandi N., Vailleau F, Nuzhdin S, Marjoram P, Rickauer M., Gentzbittel L. (Aug. 31, Sept. 1 & 4, 2015 – In the frame of the BLÅTAND Program 2015 organized by the French Embassy in Denmark) “Genetics & Genomics of Quantitative Disease Resistance against root pathogens in Medicago truncatula”. Department of Molecular Biology and Genetics (MBG), in Aarhus Univ., AU-Foulum & AU-Flakkebjerg, Denmark
Ben C, Tatarinova T, Triska M, Mazurier M, Nuzhdin S, Gentzbittel L. (Jan. 17, 2015) “Using patterns of genetic variation within modern plant accessions to reveal ancestral genome admixture and to infer population adaptation in the wild legume species Medicago truncatula”. OIST Ancient DNA Symposium, Okinawa, Japan
Ben C, Formey D, Sallet E, Lelandais-Brière C, Shamandi N, , Bustos-Sanmamed P, Niebel A, Frugier F, Combier JP, Hartmann C, Wincker P, Roux C, Gouzy J, Crespi M, Gentzbittel L. (Dec. 19, 2014) “microRNAs as key regulators of symbiotic and pathogenic root interactome in the model legume Medicago truncatula” Xishuangbanna Tropical Botanical Garden CAS, Kunming, China
Ben C, Shamandi N, Lelandais C, Hartmann C, Sallet E, Gouzy J, Rickauer M, Crespi M and Gentzbittel L. (Nov. 07, 2012) “MicroRNA regulation of the root response to stress in the model legume Medicago truncatula- Salt Stress and Root Diseases as Paradigms” Seminars of the Key Laboratory of Biodiversity and Biogeography,Kunming Institute of Botany CAS, China
Oral presentations as the speaker at international congresses:
Ben C, Lelandais C, Sallet E, Shamandi N, Gouzy J, Rickauer M, Crespi M and Gentzbittel L. (2010) "Are microRNAs involved in the root response to stress in the model legume Medicago truncatula?'.Conference on "miRNAs in plant and animal development", Nov. 2010, Paris, France
Ben C, Lelandais C, Hartmann C, Sallet E, Gouzy J, Rickauer M, Crespi M and Gentzbittel L. (2010) "microRNAs regulation of biotic and abiotic stress responses: common and specific pathways ?" International Congress on Legumes Genetics & Genomics, Satellite Workshop on 'MicroRNAs in Legumes', July 4-10, 2010, Asilomar Conference Grounds, California, USA
LIST OF PUBLICATIONS IN ISI JOURNALS
18 articles published in ISI Journals, h-index=8, # of citations: 173
Submitted, under review & in revisions
Sbeiti A, Mazurier M, Ben C, Rickauer M, Gentzbittel L. Global warming modifies root antagonistic interactions, promotes pathogen virulence and aggressiveness and may indirectly affect the distribution of resistant plant populations. Under review for Plant Pathol.
Gentzbittel L, Ben C, Mazurier M, Min-Gyoung S, Triska M, Rickauer M, Marjoram P., Nuzhdin S, Tatarinova T. Prediction of quantitative traits of adaptive relevance in plants using whole-genome population-based approach. Submitted to eLife
Kadri A, Julier B, Laouar M, Ben C, Badri M, Chedded J, Mouhouche B, Gentzbittel L, Abdelguerfi A. Genetic determinism of fitness traits under drought stress in the model legume Medicago truncatula. Final preparation.
Amokrane MSY, Kadri A, Laouar M, , Abdelguerfi A, Julier B, Ben C, Gentzbittel L. Functional traits diversity and fitness evaluation in response to salt stress in some Medicago spp wild populations. Final preparation.
Mabrouk Y, Ameline-Torregrosa C, Ben C, San Clemente H, Rotter B, Winter P, Gentzbittel L, Rickauer M. Global gene expression changes in the model legume plant Medicago truncatula in response to infection with the fungal pathogen Ascochyta pisi assessed by deep SuperSAGE. Final preparation.
Toueni M, Ben C, Leru A, Gentzbittel L, Rickauer M. (2016) Quantitative resistance to Verticillium wilt in Medicago truncatula involves eradication of the fungus from roots and is associated to transcriptional responses related to innate immunity. Frontiers in Plant Sci.,Frontiers in Plant Sci., http://dx.doi.org/10.3389/fpls.2016.01431
Youssef C., Aubry C., Montrichard F., Beucher D., Juchaux M., Ben C., Prosperi J.M., Béatrice Teulat. (2016) Cell length instead cell number becomes the predominant factor contributing to hypocotyl length genotypic differences under abiotic stress in Medicago truncatula. Physiologia Plantarum, 156: 108–124.
Rahoui S, Martinez Y, Sakouhi L, Chaoui A, Ben C, Rickauer M, Gentzbittel L, El Ferjani M. (2016) Cadmium-induced changes in antioxidative systems and differentiation in roots of contrasted Medicago truncatula lines. Protoplasma, doi: 10.1007/s00709-016-0968-9
Gentzbittel L., Andersen S.U., Ben C., Rickauer M., Stougaard J., Cook D.R., Young N.D. Naturally occuring diversity helps to reveal genes of adaptive importance in legumes. Front. Plant Sci. http://journal.frontiersin.org/article/10.3389/fpls.2015.00269/abstract
Rahoui S, Chaoui A, Ben C, Rickauer M, Gentzbittel L, El Ferjani E. (2015) Effect of cadmium pollution on mobilization of embryo reserves in seedlings of six contrasted Medicago truncatula lines. Phytochemistry, pii: S0031-9422(14)00534-2. doi: 10.1016/j.phytochem.2014.12.002. [Epub ahead of print]
Formey D*, Sallet E*, Lelandais-Brière C*, Ben C*, Bustos-Sanmamed P, Niebel A, Frugier F, Combier JP, Hartmann C, Wincker P, Roux C, Gentzbittel L, Gouzy J, Crespi M. (2014) Diversity, conservation and plasticity of the miRNAome from Medicago truncatula roots under symbiotic and pathogenic interactions, Genome Biology,15:457. (*These authors contributed equally to the work - Research highlight by Huan Wang & Nam-Hai Chua,Genome Biology 2014, 15:475)
Foroozanfar M, Exbrayat S, Gentzbittel L, Bertoni G, Maury P, Naghavie M, Peyghambari A, Badri M, Ben C, Debellé F, Sarrafi A. (2014) Genetic variability and identification of QTL affecting plant growth and chlorophyll fluorescence parameters in the model legume Medicago truncatula under control and salt conditions,Functional Plant Biology,41(9):983-1001.
Rahoui S, Ben C, Martinez Y, Chaoui A, Yamchi A, Rickauer M, Gentzbittel L, El Ferjani Ezzeddine. (2014) Oxidative injury and antioxidant genes regulation in six Medicago truncatula genotypes in response to cadmium treatment. Environmental Science and Pollution Research, 21(13): 8070.
Negahi A, Ben C, Gentzbittel L, Maury P, Nabipour AR, Ebrahimi A, Sarrafi A, Rickauer M.Quantitative trait loci associated with resistance to a potato isolate of Verticillium albo-atrum in Medicago truncatula. (2014) Plant Pathol., 63(2): 308–315.
Ben C, Debellé F, Berges H, Bellec A, Jardinaud MF, Anson P, Huguet T, Gentzbittel L, Vailleau F. (2013) MtQRRS1, a R-locus required for Medicago truncatula Quantitative Resistance to Ralstonia solanacearum. New Phytol.199(3):758-72.
Ben C, Toueni M, Montanari S, Tardin MC, Fervel M, Negahi A, Saint-Pierre L, Mathieu G, Gras MC, Noël D, Prospéri JM, Pilet-Nayel ML, Baranger A, Huguet T, Julier B, Rickauer M, Gentzbittel L. (2013) Natural diversity in the model legume Medicago truncatula allows identifying distinct genetic mechanisms conferring partial resistance to Verticillium wilt. J Exp Bot. 64(1):317-32.
Negahi A, Sarrafi A, Ebrahimi A, Maury P, Prospéri JM, Ben C, Rickauer M. (2013). Genetic variability of tolerance to Verticillium albo-atrum and Verticillium dahliae in Medicago truncatula, Eur. J Plant Pathol., 136:135–143.
Yang Y, Chen J, Liu Q, Ben C, Todd CD, Shi J, Yang Y, Hu X. (2012) Comparative Proteomic Analysis of the Thermotolerant Plant Portulaca oleracea Acclimation to Combined High Temperature and Humidity Stress. J Proteome Res. 11(7):3605-23.
Moreau D, Burstin J, Aubert G, Huguet T, Ben C, Prosperi JM, Salon C, Munier-Jolain N. (2012) Using a physiological framework for improving the detection of quantitative trait loci related to nitrogen nutrition in Medicago truncatula.Theor Appl Genet. 124(4):755-68.
Branca A, Paape T, Zhou P, Briskine R, Farmer A, Mudge J, Bharti A, Woodward J, May G, Gentzbittel L, Ben C, Denny R, Sadowsky M, Ronfort J, Bataillon T, Young N, Tiffin P (2011) Whole-genome nucleotide diversity, recombination, and linkage-disequilibrium in the model legume Medicago truncatula. PNAS 108(42):E864-70.
Stewart S, Hodge S, Mansfield J, Prosperi JM, Huguet T, Ben C, Gentzbittel L, Powell G. (2009) The RAP1 gene confers extreme resistance to the pea aphid in Medicago truncatula without engaging the hypersensitive reaction. Mol. Plant-Microbe Interact. 12, 1645-1655.
Ben C, Hewezi T, Jardinaud MF, Bena F, Ladouce N, Moretti S, Tamborindeguy C, Liboz T, Petitprez M, Gentzbittel L. (2005) Comparative analysis of early embryonic sunflower cDNA libraries. Plant Mol Biol. 57(2):255-70.
Tamborindeguy C, Ben C, Liboz T, Gentzbittel L. (2004) Sequence evaluation of four specific cDNA libraries for developmental genomics of sunflower. Mol Genet Genomics. 271(3):367-75.
Tamborindeguy C, Ben C, Jardinaud F, Gentzbittel L, Liboz T. (2004) Mass cloning of differential and non differential transcript-derived fragments from cDNA-AFLP experiments in sunflower. Plant Mol. Biol. Rep. 22(2):165-171.
Involvement in national and international funded collaborative research programs
French leader of the MeToliCa PICS project (International Project for Scientific Cooperation) funded by the CNRS (French PI: C. BEN, ECOLAB; and Chinese PI: XY Hu, KIB/CAS)
'Towards an integrative approach to unravel the biodiversity and molecular response to cadmium stress in the wild legume Medicago truncatula'
Member of PHC Utique French-Tunisian Program, funded by Campus France Agency (French PI: M. Rickauer/L. Gentzbittel, ECOLAB; Tunisian PI: Y. Mabrouk/M. Badri)
'Potential of Rhizobium strains for biocontrol of Verticillium wilt in legumes'
'Analysis of genetic basis and physiological mechanisms of the interaction salinity/pathogens in Medicago truncatula'
Member of PHC Tassili French-Algerian Program, funded by Campus France Agency (French PI: B. Julier, INRA Lusignan, French co-PI: L. Gentzbittel, ECOLAB; and Algerian PI: A. Abdelguerfi, ENSA Alger)
‘Genetics of tolerance to drought in lucerne’
French leader of PHC Xu Guangqi 2012 French-Chinese Program funded by the French Embassy in China (French PI: C. BEN, ECOLAB; and Chinese PI: XY Hu, KIB/CAS)
‘Analysis of the molecular response to cadmium in the model legume Medicago truncatula.’
(Yang et al., 2012 as a side project)
Member of the NodON/NodOFF ANR national Project, funded by the French Agency for Research ANR(PI: F. Debellé, LIPM)
‘New genetic approaches to analyse the host spectrum in the symbiosis Rhizobium-Legumes’(Foroozanfar et al., Funct. Plant Biol. as a side project)
Member of the 'MIRMED' national collaborative project funded by the Genoscope (PI: M. Crespi, ISV)
‘High throughput sequencing of small RNAs in Medicago truncatula’(Formey D*, Sallet E*, Lelandais-Brière C*, Ben C* et al., Genome Biol., 2014)
Member of the national 'Contrat de Branche' Project on 'Resistance to Bio-agressors', funded by the French Ministry of Agriculture and involving private seed companies and public research institutes
‘Genetics of resistance to pathogens in Legumes’(Ben et al., J. Exp. Bot, 2013)
Member of the NSF Plant Genome Research Project 'Medicago truncatula HapMap' (PI: N.D. Young, University of Minnesota, USA)
(Branca et al., PNAS,2011–Website: http://www.medicagohapmap.org/home/view)
Participation to the NSF Plant Genome Research Project ‘GEPR: Community Genomics of Local Adaptation in Medicago truncatula’ (PI: Sergey Nuzhdin, USC Los Angeles, USA)
Informal current collaborations
-Pr E. Elferjani, F.S.B, Université de Carthage, Tunisia ‘Genetics of Cadmium tolerance in M. truncatula’
(Rahoui et al., ESPR, 2014; Rahoui et al., Phytochemistry, 2015)
-Dr T. Tatarinova, USC Los Angeles, USA ‘Medicago truncatula Population Genomics’(Gentzbittel et al.,pending submission to Ecology Letters)
-Dr J.J. Drevon & Dr G. Carlson, INRA Montpellier, France ‘Genetics of tolerance to phosphorus deﬁciency in M. truncatula’
-PICS CNRS 2014-2016 (International Project for Scientific Cooperation)
Research grant from the CNRS to strengthen and formalize the established collaboration on the study of ‘cadmium tolerance in plants’ with Pr Xiang Yang HU, Key Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany CAS, China.
- Xu Guangqi Program 2012
Research grant from the French Embassy in China to help to the development of a starting collaboration on the study of ‘cadmium tolerance in plants’ with Pr Xiang Yang HU, Key Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany CAS, China.
'Genetics and Plant Breeding' (>200h/year)
for Engineer students in Agronomy (INP-ENSAT) and for Graduate students of the International AgroFood Chain Master (Univ. of Toulouse – Courses performed in english).
Temporary Assistant Professor
'Plant Nutrition’and‘Statistics (experimental designs)'(96h/year)
for Engineer students in Agronomy (University of Toulouse, INP-ENSAT).
Organization of an International Course
“Quantitative genetics of agronomical traits of interest” (8-11 June 2015, Center of Biotechnology of Borj Cedria, Tunisia)
Participation to teaching workshops
-'Approche par compétences' (Sept. 23, 2015 - J. Tardif, Univ. Sherbrook) organized by INP-ENSAT.
- ‘Apprentissage Par Problèmes et Apprentissage Par Projets’ (Oct. 24, 2013) organized by the Service inter Universitaire de Pédagogie, Univ. of Toulouse.
-Member of the scientific advisory board of F1 genomics, a private company in the field of agrogenomics (http://www.f1genomics.com/about2.html).
-Member of the International Legume Society (ILS) and of the French Society of Phytopathology (SFP)